At Sever Pharma Solutions, we have experience with a wide range of different injection molding processes and scales. We can injection mold most materials, including silicone and thermoplastics, with or without active ingredients. Injection molding of delivery systems, which are supposed to release one or more drugs require specific process and formulation knowledge. For example, processing conditions and interactions with reactive polymers may affect product stability and performance. Based on our experience we are confident that our scientist can contributes to the successful development of your injection molding product.
We can injection mold from the first small technical trials, using manual molding techniques to save time and materials. Small-scale injection molding can be performed in a non-cGMP environment or in accordance with cGMP. The injection molding process has many attributes that can be kept constant following scale-up from initial small-scale technical trials, while other parameters may still require optimization before “locking the process” for commercial production at the clinical development phase.
Sometimes the challenge is to design a product that can be efficiently injection molded and therefore be suitable for commercial production. For example, the product shape should be suitable for molding, it may be necessary to combine materials in co-injection molding, or surface treatment of the mold may be required. We have in-house expertise in mold design and work together with closely situated experts in mold manufacture and surface treatment of molds.
Silicone matrix rings are a popular format for vaginal rings due to their simple design. Even so, there are often challenges to solve due to special requirements of the API or when optimizing the process to ensure that it is both efficient and economical. The complexities of mixing the API into the silicone should also not be underestimated. This can be performed by different processes, e.g., continuous dynamic mixing or batch-wise mechanical reactor. Together we can choose the most advantageous solution for your product.